Inhaling poppers relaxes smooth muscles throughout the body, including the sphincter muscles of the anus and the vagina. This causes the blood vessels to dilate (which causes a sudden drop in blood pressure), increases heart rate, and produces a sensation of heat and excitement that usually lasts for a couple of minutes.
Poppers are often used as a club drug or to enhance a sexual experience. The head rush, euphoria, laughter or giggling, and other sensations that result from the drop in blood pressure are often felt to increase sexual arousal and desire. At the same time, the relaxation of the sphincters of the anus and vagina can make penetration easier and can enhance and prolong orgasms for both men and women.
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